Constitutive Interleukin-7 Cytokine Signaling Enhances the Persistence of Epstein–Barr Virus-Specific T-Cells

The efficacy of therapeutic T-cells is limited by a lack of positive signals and excess inhibitory signaling in tumor microenvironments. We previously showed that a constitutively active IL7 receptor (C7R) enhanced the persistence, expansion, and anti-tumor activity of T-cells expressing chimeric an...

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Detalles Bibliográficos
Autores principales: Sharma, Sandhya, Sauer, Tim, Omer, Bilal A., Shum, Thomas, Rollins, Lisa A., Rooney, Cliona M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10649234/
https://www.ncbi.nlm.nih.gov/pubmed/37958791
http://dx.doi.org/10.3390/ijms242115806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10649234/
https://www.ncbi.nlm.nih.gov/pubmed/37958791
http://dx.doi.org/10.3390/ijms242115806

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