Glucokinase Variant Proteins Are Resistant to Fasting-Induced Uridine Diphosphate Glucose-Dependent Degradation in Maturity-Onset Diabetes of the Young Type 2 Patients

We previously reported that glucokinase undergoes ubiquitination and subsequent degradation, a process mediated by cereblon, particularly in the presence of uridine diphosphate glucose (UDP-glucose). In this context, we hereby present evidence showcasing the resilience of variant glucokinase protein...

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Detalles Bibliográficos
Autores principales: Cho, Jaeyong, Horikawa, Yukio, Oiwa, Yuki, Hosomichi, Kazuyoshi, Yabe, Daisuke, Imai, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10649437/
https://www.ncbi.nlm.nih.gov/pubmed/37958824
http://dx.doi.org/10.3390/ijms242115842

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10649437/
https://www.ncbi.nlm.nih.gov/pubmed/37958824
http://dx.doi.org/10.3390/ijms242115842

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