Cargando…
Pioglitazone Protects Tubular Epithelial Cells during Kidney Fibrosis by Attenuating miRNA Dysregulation and Autophagy Dysfunction Induced by TGF-β
Excessive renal TGF-β production and pro-fibrotic miRNAs are important drivers of kidney fibrosis that lack any efficient treatment. Dysfunctional autophagy might play an important role in the pathogenesis. We aimed to study the yet unknown effects of peroxisome proliferator-activated receptor-γ (PP...
Autores principales: | Manzéger, Anna, Garmaa, Gantsetseg, Mózes, Miklós M., Hansmann, Georg, Kökény, Gábor |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10649561/ https://www.ncbi.nlm.nih.gov/pubmed/37958504 http://dx.doi.org/10.3390/ijms242115520 |
Ejemplares similares
-
The PPARγ agonist pioglitazone prevents TGF-β induced renal fibrosis by repressing EGR-1 and STAT3
por: Németh, Ágnes, et al.
Publicado: (2019) -
PPARγ and TGFβ—Major Regulators of Metabolism, Inflammation, and Fibrosis in the Lungs and Kidneys
por: Kökény, Gábor, et al.
Publicado: (2021) -
Sustained hyperosmolarity increses TGF-ß1 and Egr-1 expression in the rat renal medulla
por: Mózes, Miklós M., et al.
Publicado: (2017) -
Pioglitazone Attenuates Vascular Fibrosis in Spontaneously Hypertensive Rats
por: Gao, Dengfeng, et al.
Publicado: (2012) -
Olmesartan Attenuates Kidney Fibrosis in a Murine Model of Alport Syndrome by Suppressing Tubular Expression of TGFβ
por: Suh, Sang Heon, et al.
Publicado: (2019)