Loss of ADAR1 in macrophages in combination with interferon gamma suppresses tumor growth by remodeling the tumor microenvironment

BACKGROUND: ADAR1, the major enzyme for RNA editing, has emerged as a tumor-intrinsic key determinant for cancer immunotherapy efficacy through modulating interferon-mediated innate immunity. However, the role of ADAR1 in innate immune cells such as macrophages remains unknown. METHODS: We first ana...

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Detalles Bibliográficos
Autores principales: Lin, Weiwei, Luo, Yikai, Wu, Jie, Zhang, Haowan, Jin, Ge, Guo, Chahua, Zhou, Hang, Liang, Han, Xu, Xiaoyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10649901/
https://www.ncbi.nlm.nih.gov/pubmed/37935565
http://dx.doi.org/10.1136/jitc-2023-007402

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10649901/
https://www.ncbi.nlm.nih.gov/pubmed/37935565
http://dx.doi.org/10.1136/jitc-2023-007402

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