Repurposing Drugs for Inhibition against ALDH2 via a 2D/3D Ligand-Based Similarity Search and Molecular Simulation

Aldehyde dehydrogenase-2 (ALDH2) is a crucial enzyme participating in intracellular aldehyde metabolism and is acknowledged as a potential therapeutic target for the treatment of alcohol use disorder and other addictive behaviors. Using previously reported ALDH2 inhibitors of Daidzin, CVT-10216, and...

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Detalles Bibliográficos
Autores principales: Jiang, Wanyun, Chen, Junzhao, Zhang, Puyu, Zheng, Nannan, Ma, Le, Zhang, Yongguang, Zhang, Haiyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650273/
https://www.ncbi.nlm.nih.gov/pubmed/37959744
http://dx.doi.org/10.3390/molecules28217325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650273/
https://www.ncbi.nlm.nih.gov/pubmed/37959744
http://dx.doi.org/10.3390/molecules28217325

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