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Inflammatory Bone Marrow Mesenchymal Stem Cells in Multiple Myeloma: Transcriptional Signature and In Vitro Modeling

SIMPLE SUMMARY: Multiple myeloma cells mainly proliferate in the bone marrow (BM). Mesenchymal stem cells (MSCs) in the BM of MM patients are tumor supportive and exhibit an inflammatory transcription signature and contribute to drug resistance. Due to their rarity in the BM, downstream functional c...

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Detalles Bibliográficos
Autores principales: Wang, Lei, Yi, Weijun, Ma, Li, Lecea, Emily, Hazlehurst, Lori A., Adjeroh, Donald A., Hu, Gangqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650304/
https://www.ncbi.nlm.nih.gov/pubmed/37958322
http://dx.doi.org/10.3390/cancers15215148