A Serine Protease Inhibitor, Camostat Mesilate, Suppresses Urinary Plasmin Activity and Alleviates Hypertension and Podocyte Injury in Dahl Salt-Sensitive Rats

In proteinuric renal diseases, the serine protease (SP) plasmin activates the epithelial sodium channel (ENaC) by cleaving its γ subunit. We previously demonstrated that a high-salt (HS) diet provoked hypertension and proteinuria in Dahl salt-sensitive (DS) rats, accompanied by γENaC activation, whi...

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Detalles Bibliográficos
Autores principales: Iwata, Yasunobu, Deng, Qinyuan, Kakizoe, Yutaka, Nakagawa, Terumasa, Miyasato, Yoshikazu, Nakagawa, Miyuki, Nishiguchi, Kayo, Nagayoshi, Yu, Narita, Yuki, Izumi, Yuichiro, Kuwabara, Takashige, Adachi, Masataka, Mukoyama, Masashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650472/
https://www.ncbi.nlm.nih.gov/pubmed/37958726
http://dx.doi.org/10.3390/ijms242115743

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650472/
https://www.ncbi.nlm.nih.gov/pubmed/37958726
http://dx.doi.org/10.3390/ijms242115743

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