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Carbonic Anhydrase Inhibitors Induce Ferroptosis through Inhibition of AKT/FTH1 Signaling in Ewing Sarcoma Tumor Cells

SIMPLE SUMMARY: Ewing sarcoma (ES) is one of the most common kinds of cancer in youngsters, and ES relapse after therapy treatment remains a problem. Carbonic anhydrases (CAs; EC 4.2.1.1) have emerged as interesting molecular targets for the development of anticancer medicines as a fundamental regul...

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Detalles Bibliográficos
Autores principales: Fayzullina, Darya, Yakushov, Semyon, Kantserova, Kamilla, Belyaeva, Elizaveta, Aniskin, Denis, Tsibulnikov, Sergey, Fayzullina, Nafisa, Kalinin, Stanislav, Romantsova, Olga, Timashev, Peter S., Schroeder, Brett A., Ulasov, Ilya V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650537/
https://www.ncbi.nlm.nih.gov/pubmed/37958399
http://dx.doi.org/10.3390/cancers15215225