In Silico Molecular Docking and Dynamics Simulation Analysis of Potential Histone Lysine Methyl Transferase Inhibitors for Managing β-Thalassemia

A decreased hemoglobin synthesis is contemplated as a pathological indication of β-thalassemia. Recent studies show that EPZ035544 from Epizyme could induce fetal hemoglobin (HbF) levels due to its proven capability to inhibit euchromatin histone lysine methyl transferase (EHMT2). Therefore, the dev...

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Detalles Bibliográficos
Autores principales: Ravikumar, Yuvaraj, Koonyosying, Pimpisid, Srichairatanakool, Sirichai, Ponpandian, Lakshmi Naryanan, Kumaravelu, Jayanthi, Srichairatanakool, Somdet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650625/
https://www.ncbi.nlm.nih.gov/pubmed/37959685
http://dx.doi.org/10.3390/molecules28217266

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650625/
https://www.ncbi.nlm.nih.gov/pubmed/37959685
http://dx.doi.org/10.3390/molecules28217266

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