The Repurposing of Non-Peptide Neurokinin-1 Receptor Antagonists as Antitumor Drugs: An Urgent Challenge for Aprepitant

The substance P (SP)/neurokinin-1 receptor (NK-1R) system is involved in cancer progression. NK-1R, activated by SP, promotes tumor cell proliferation and migration, angiogenesis, the Warburg effect, and the prevention of apoptosis. Tumor cells overexpress NK-1R, which influences their viability. A...

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Detalles Bibliográficos
Autores principales: Coveñas, Rafael, Rodríguez, Francisco D., Robinson, Prema, Muñoz, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650658/
https://www.ncbi.nlm.nih.gov/pubmed/37958914
http://dx.doi.org/10.3390/ijms242115936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650658/
https://www.ncbi.nlm.nih.gov/pubmed/37958914
http://dx.doi.org/10.3390/ijms242115936

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