Epigenetic Profiling of PTPN11 Mutant JMML Hematopoietic Stem and Progenitor Cells Reveals an Aberrant Histone Landscape

SIMPLE SUMMARY: Juvenile myelomonocytic leukemia (JMML) is a deadly pediatric leukemia with limited treatment options and poor clinical outcomes. Effective targeted treatment strategies are an urgent unmet need. To improve outcomes for this pediatric patient population, we examined the structure of...

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Detalles Bibliográficos
Autores principales: Sinha, Roshani, Dvorak, Mai, Ganesan, Ananthakrishnan, Kalesinskas, Larry, Niemeyer, Charlotte M., Flotho, Christian, Sakamoto, Kathleen M., Lacayo, Norman, Patil, Rachana Vinay, Perriman, Rhonda, Cepika, Alma-Martina, Liu, Yunying Lucy, Kuo, Alex, Utz, Paul J., Khatri, Purvesh, Bertaina, Alice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650722/
https://www.ncbi.nlm.nih.gov/pubmed/37958378
http://dx.doi.org/10.3390/cancers15215204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650722/
https://www.ncbi.nlm.nih.gov/pubmed/37958378
http://dx.doi.org/10.3390/cancers15215204

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