Leveraging the Fragment Molecular Orbital Method to Explore the PLK1 Kinase Binding Site and Polo-Box Domain for Potent Small-Molecule Drug Design

Polo-like kinase 1 (PLK1) plays a pivotal role in cell division regulation and emerges as a promising therapeutic target for cancer treatment. Consequently, the development of small-molecule inhibitors targeting PLK1 has become a focal point in contemporary research. The adenosine triphosphate (ATP)...

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Detalles Bibliográficos
Autores principales: Jin, Haiyan, Kim, Jongwan, Lee, Onju, Kim, Hyein, No, Kyoung Tai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650754/
https://www.ncbi.nlm.nih.gov/pubmed/37958623
http://dx.doi.org/10.3390/ijms242115639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650754/
https://www.ncbi.nlm.nih.gov/pubmed/37958623
http://dx.doi.org/10.3390/ijms242115639

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