Cargando…

Synthesis and In Vivo Antiarrhythmic Activity Evaluation of Novel Scutellarein Analogues as Voltage-Gated Nav1.5 and Cav1.2 Channels Blockers

Malignant cardiac arrhythmias with high morbidity and mortality have posed a significant threat to our human health. Scutellarein, a metabolite of Scutellarin which is isolated from Scutellaria altissima L., presents excellent therapeutic effects on cardiovascular diseases and could further be metab...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Wei, Wang, Wenping, Cai, Song, Li, Peng, Zhang, Die, Ning, Jinhua, Ke, Jin, Hou, Anguo, Chen, Linyun, Ma, Yunshu, Jin, Wenbin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650756/ https://www.ncbi.nlm.nih.gov/pubmed/37959836 http://dx.doi.org/10.3390/molecules28217417

Ejemplares similares

Effects of acidosis on neuronal voltage-gated sodium channels: Nav1.1 and Nav1.3
por: Ghovanloo, Mohammad-Reza, et al.
Publicado: (2018)

Bidirectional Modulation of the Voltage-Gated Sodium (Nav1.6) Channel by Rationally Designed Peptidomimetics
por: Dvorak, Nolan M., et al.
Publicado: (2020)

The Functional Role of Voltage-Gated Sodium Channel Nav1.5 in Metastatic Breast Cancer
por: Luo, Qianxuan, et al.
Publicado: (2020)

Role of the voltage-gated sodium channel Nav1.6 in glioma and candidate drugs screening
por: Ai, Yong, et al.
Publicado: (2023)

Phosphorylation of a chronic pain mutation in the voltage-gated sodium channel Nav1.7 increases voltage sensitivity
por: Kerth, Clara M., et al.
Publicado: (2020)

Na(+)/Ca(2+) selectivity in the bacterial voltage-gated sodium channel NavAb
por: Corry, Ben
Publicado: (2013)

The Sigma-1 Receptor Binds to the Nav1.5 Voltage-gated Na(+) Channel with 4-Fold Symmetry
por: Balasuriya, Dilshan, et al.
Publicado: (2012)

Voltage sensor dynamics of a bacterial voltage-gated sodium channel NavAb reveal three conformational states
por: Han, Shuo, et al.
Publicado: (2023)

Solution Structure of Kurtoxin: A Gating Modifier Selective for Cav3 Voltage-Gated Ca(2+) Channels
por: Lee, Chul Won, et al.
Publicado: (2012)

Cavβ1 regulates T cell expansion and apoptosis independently of voltage-gated Ca(2+) channel function
por: Erdogmus, Serap, et al.
Publicado: (2022)

Elevated Neuronal Excitability Due to Modulation of the Voltage-Gated Sodium Channel Nav1.6 by Aβ(1−42)
por: Wang, Xi, et al.
Publicado: (2016)

Action of Clathrodin and Analogues on Voltage-Gated Sodium Channels
por: Peigneur, Steve, et al.
Publicado: (2014)

Synthesis and Bioactivity Characterization of Scutellarein Sulfonated Derivative
por: Gu, Ting, et al.
Publicado: (2017)

MiR-30b Attenuates Neuropathic Pain by Regulating Voltage-Gated Sodium Channel Nav1.3 in Rats
por: Su, Songxue, et al.
Publicado: (2017)

Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal
por: Harrison, Paul J., et al.
Publicado: (2020)

Erratum to: Voltage-gated Sodium Channels and Blockers: An Overview and Where Will They Go?
por: Li, Zhi-mei, et al.
Publicado: (2021)

An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin
por: Dong, Ze-Xi, et al.
Publicado: (2016)

Modeling of the Binding of Peptide Blockers to Voltage-Gated Potassium Channels: Approaches and Evidence
por: Novoseletsky, V. N., et al.
Publicado: (2016)

Thermal melt circular dichroism spectroscopic studies for identifying stabilising amphipathic molecules for the voltage‐gated sodium channel NavMs
por: Ireland, Sam M., et al.
Publicado: (2017)

Antiarrhythmic calcium channel blocker verapamil inhibits trek currents in sympathetic neurons
por: Herrera-Pérez, S., et al.
Publicado: (2022)

Scutellarein Reduces Inflammatory Responses by Inhibiting Src Kinase Activity
por: Sung, Nak Yoon, et al.
Publicado: (2015)

Predictive QSAR model confirms flavonoids in Chinese medicine can activate voltage-gated calcium (CaV) channel in osteogenesis
por: Chan, Ki, et al.
Publicado: (2020)

Comparative Metabolomic Analysis of the Neuroprotective Effects of Scutellarin and Scutellarein against Ischemic Insult
por: Tang, Hao, et al.
Publicado: (2015)

Novel SCN1A mutation in the IFMT motif of the α1 subunit of the voltage-gated NaV1.1 channel causing familial hemiplegic migraine
por: De Vries, B, et al.
Publicado: (2013)

Goshajinkigan, a Traditional Japanese Medicine, Suppresses Voltage-Gated Sodium Channel Nav1.4 Currents in C2C12 Cells
por: Imai, Ryota, et al.
Publicado: (2020)

Antiepileptic Drug Tiagabine Does Not Directly Target Key Cardiac Ion Channels Kv11.1, Nav1.5 and Cav1.2
por: Kowalska, Magdalena, et al.
Publicado: (2021)

Tramadol as a Voltage-Gated Sodium Channel Blocker of Peripheral Sodium Channels Na(v)1.7 and Na(v)1.5
por: Bok, Chan-Su, et al.
Publicado: (2023)

PITX2 Modulates Atrial Membrane Potential and the Antiarrhythmic Effects of Sodium-Channel Blockers
por: Syeda, Fahima, et al.
Publicado: (2016)

Anti‐Inflammatory and Antiarrhythmic Effects of Beta Blocker in a Rat Model of Rheumatoid Arthritis
por: Lin, Ting‐Tse, et al.
Publicado: (2020)

The voltage‐gated calcium channel CaV1.2 promotes adult oligodendrocyte progenitor cell survival in the mouse corpus callosum but not motor cortex
por: Pitman, Kimberley A., et al.
Publicado: (2019)

Dysfunction of NaV1.4, a skeletal muscle voltage-gated sodium channel, in sudden infant death syndrome: a case-control study
por: Männikkö, Roope, et al.
Publicado: (2018)

Expression and Role of Voltage-Gated Sodium Channels in Human Dorsal Root Ganglion Neurons with Special Focus on Nav1.7, Species Differences, and Regulation by Paclitaxel
por: Chang, Wonseok, et al.
Publicado: (2017)

3’-O-Methylorobol Inhibits the Voltage-Gated Sodium Channel Nav1.7 with Anti-Itch Efficacy in A Histamine-Dependent Itch Mouse Model
por: Zhang, Fan, et al.
Publicado: (2019)

Voltage-Sensing Domain of the Third Repeat of Human Skeletal Muscle NaV1.4 Channel As a New Target for Spider Gating Modifier Toxins
por: Myshkin, M. Yu., et al.
Publicado: (2021)

Synthesis and Protective Effect of Scutellarein on Focal Cerebral Ischemia/Reperfusion in Rats
por: Qian, Lihua, et al.
Publicado: (2012)

Artificial pore blocker acts specifically on voltage-gated potassium channel isoform K(V)1.6
por: Gigolaev, Andrei M., et al.
Publicado: (2022)

Designing a C(84) fullerene as a specific voltage-gated sodium channel blocker
por: Hilder, Tamsyn A, et al.
Publicado: (2013)

Expression of voltage-gated sodium channel Nav1.5 in non-metastatic colon cancer and its associations with estrogen receptor (ER)-β expression and clinical outcomes
por: Peng, Jianhong, et al.
Publicado: (2017)

Identification and Characterization of Novel Proteins from Arizona Bark Scorpion Venom That Inhibit Nav1.8, a Voltage-Gated Sodium Channel Regulator of Pain Signaling
por: Abd El-Aziz, Tarek Mohamed, et al.
Publicado: (2021)

Distribution of Voltage-Gated Sodium Channel (Nav) Alleles among the Aedes aegypti Populations In Central Java Province and Its Association with Resistance to Pyrethroid Insecticides
por: Sayono, Sayono, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_t1hamn18levsf2llp0f2sub2t5