Targeting Translation and the Cell Cycle Inversely Affects CTC Metabolism but Not Metastasis

SIMPLE SUMMARY: This study identifies specific ribosomal proteins that drive MBM and extracranial metastasis via CTCs. Dual targeting of cellular translation and proliferation prevents metastasis of aggressive CTC subsets with high RPL/RPS expression. We report the first-ever real-time metabolic flu...

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Detalles Bibliográficos
Autores principales: Bowley, Tetiana Y., Merkley, Seth D., Lagutina, Irina V., Ortiz, Mireya C., Lee, Margaret, Tawfik, Bernard, Marchetti, Dario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650766/
https://www.ncbi.nlm.nih.gov/pubmed/37958436
http://dx.doi.org/10.3390/cancers15215263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650766/
https://www.ncbi.nlm.nih.gov/pubmed/37958436
http://dx.doi.org/10.3390/cancers15215263

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