Discovery, Structure–Activity Relationship and In Vitro Anticancer Activity of Small-Molecule Inhibitors of the Protein–Protein Interactions between AF9/ENL and AF4 or DOT1L

SIMPLE SUMMARY: Chromosomal translocations involving the mixed lineage leukemia (MLL) gene generate potent fusion oncogenes and cause acute myeloid leukemia or lymphocytic leukemia, which account for ~75% infant and 5–10% child/adult acute leukemia cases with a poor prognosis (5-year survival rates...

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Detalles Bibliográficos
Autores principales: Li, Xin, Wu, Xiaowei, Nie, Shenyou, Zhao, Jidong, Yao, Yuan, Wu, Fangrui, Mishra, Chandra Bhushan, Ashraf-Uz-Zaman, Md, Moku, Bala Krishna, Song, Yongcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650850/
https://www.ncbi.nlm.nih.gov/pubmed/37958457
http://dx.doi.org/10.3390/cancers15215283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650850/
https://www.ncbi.nlm.nih.gov/pubmed/37958457
http://dx.doi.org/10.3390/cancers15215283

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