Top-Down Proteomics of Mouse Islets With Beta Cell CPE Deletion Reveals Molecular Details in Prohormone Processing

Altered prohormone processing, such as with proinsulin and pro-islet amyloid polypeptide (proIAPP), has been reported as an important feature of prediabetes and diabetes. Proinsulin processing includes removal of several C-terminal basic amino acids and is performed principally by the exopeptidase c...

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Detalles Bibliográficos
Autores principales: Fulcher, James M, Swensen, Adam C, Chen, Yi-Chun, Verchere, C Bruce, Petyuk, Vladislav A, Qian, Wei-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650973/
https://www.ncbi.nlm.nih.gov/pubmed/37967211
http://dx.doi.org/10.1210/endocr/bqad160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650973/
https://www.ncbi.nlm.nih.gov/pubmed/37967211
http://dx.doi.org/10.1210/endocr/bqad160

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