Cargando…

Top-Down Proteomics of Mouse Islets With Beta Cell CPE Deletion Reveals Molecular Details in Prohormone Processing

Altered prohormone processing, such as with proinsulin and pro-islet amyloid polypeptide (proIAPP), has been reported as an important feature of prediabetes and diabetes. Proinsulin processing includes removal of several C-terminal basic amino acids and is performed principally by the exopeptidase c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fulcher, James M, Swensen, Adam C, Chen, Yi-Chun, Verchere, C Bruce, Petyuk, Vladislav A, Qian, Wei-Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650973/ https://www.ncbi.nlm.nih.gov/pubmed/37967211 http://dx.doi.org/10.1210/endocr/bqad160

Ejemplares similares

Association of newly synthesized islet prohormones with intracellular membranes
Publicado: (1984)

Informed-Proteomics: Open Source Software Package for Top-down Proteomics
por: Park, Jungkap, et al.
Publicado: (2017)

Advances and Challenges in Islet Transplantation: Islet Procurement Rates and Lessons Learned from Suboptimal Islet Transplantation
por: Plesner, Annette, et al.
Publicado: (2011)

A Python Analytical Pipeline to Identify Prohormone Precursors and Predict Prohormone Cleavage Sites
por: Southey, Bruce R., et al.
Publicado: (2008)

Comparison of prohormone-processing activities in islet microsomes and secretory granules: evidence for distinct converting enzymes for separate islet prosomatostatins
Publicado: (1984)

Organization of the cpe Locus in CPE-Positive Clostridium perfringens Type C and D Isolates
por: Li, Jihong, et al.
Publicado: (2010)

Clostridium Perfringens Enterotoxin (CPE) and CPE-Binding Domain (c-CPE) for the Detection and Treatment of Gynecologic Cancers
por: Black, Jonathan D., et al.
Publicado: (2015)

Expression of mutant ELH prohormones in AtT-20 cells: the relationship between prohormone processing and sorting
Publicado: (1993)

ISDN CPE : Market and technology trends
Publicado: (1996)

A small molecule improves diabetes in mice expressing human islet amyloid polypeptide
por: Bhagat, Vriti, et al.
Publicado: (2023)

Islet Macrophages Shift to a Reparative State following Pancreatic Beta-Cell Death and Are a Major Source of Islet Insulin-like Growth Factor-1
por: Nackiewicz, Dominika, et al.
Publicado: (2019)

2165. Risk Factors for CPE Colonization in Household Contacts of CPE Colonized/Infected Patients
por: Farooqi, Lubna, et al.
Publicado: (2018)

Prohormones in the Early Diagnosis of Cardiac Syncope
por: Badertscher, Patrick, et al.
Publicado: (2017)

Top-Down Proteomics of Medicinal Cannabis
por: Vincent, Delphine, et al.
Publicado: (2019)

Islet Remodeling in Female Mice with Spontaneous Autoimmune and Streptozotocin-Induced Diabetes
por: Plesner, Annette, et al.
Publicado: (2014)

Optimized Proteome Reduction for Integrative Top–Down Proteomics
por: Woodland, Breyer, et al.
Publicado: (2023)

Exosomal Carboxypeptidase E (CPE) and CPE-shRNA-Loaded Exosomes Regulate Metastatic Phenotype of Tumor Cells
por: Hareendran, Sangeetha, et al.
Publicado: (2022)

First survey and functional annotation of prohormone and convertase genes in the pig
por: Porter, Kenneth I, et al.
Publicado: (2012)

Improving Islet Engraftment by Gene Therapy
por: Wang, Xiaojie, et al.
Publicado: (2011)

Identification of prohormones and pituitary neuropeptides in the African cichlid, Astatotilapia burtoni
por: Hu, Caroline K., et al.
Publicado: (2016)

T cells accumulate in non-diabetic islets during ageing
por: Denroche, Heather C., et al.
Publicado: (2021)

The emergence of top-down proteomics in clinical research
por: Savaryn, John P, et al.
Publicado: (2013)

Unraveling the Diversity of Co-Colonization by CPE
por: Levi, Gabrielle, et al.
Publicado: (2022)

Incidence and Time-to-Onset of Carbapenemase-Producing Enterobacterales (CPE) Infections in CPE Carriers: a Retrospective Cohort Study
por: Hoellinger, B., et al.
Publicado: (2022)

Top-Down Beta Enhances Bottom-Up Gamma
por: Richter, Craig G., et al.
Publicado: (2017)

Characterization of the prohormone complement in cattle using genomic libraries and cleavage prediction approaches
por: Southey, Bruce R, et al.
Publicado: (2009)

Incomplete posttranslational prohormone modifications in hyperactive neuroendocrine cells
por: Strating, Jeroen RPM, et al.
Publicado: (2009)

Extensive conservation of the proneuropeptide and peptide prohormone complement in mollusks
por: De Oliveira, A. L., et al.
Publicado: (2019)

512. Healthcare-Acquired (HA) Carbapenemase-Producing Enterobacteriales (CPE) in Southern Ontario, Canada: To Whom Are We Transmitting CPE?
por: Jamal, Alainna, et al.
Publicado: (2019)

Audit and feedback as a tool to increase compliance with carbapenemase-producing Enterobacteriaceae (CPE) screening and decrease CPE transmission in the hospital
por: Ben Natan, Orna, et al.
Publicado: (2023)

Comparative Analysis of Neuropeptides in Homologous Interneurons and Prohormone Annotation in Nudipleuran Sea Slugs
por: Lee, Colin A., et al.
Publicado: (2021)

Applying Label-Free Quantitation to Top Down Proteomics
por: Ntai, Ioanna, et al.
Publicado: (2014)

Top-Down Proteomics and Farm Animal and Aquatic Sciences
por: Campos, Alexandre M.O., et al.
Publicado: (2016)

A photo-cleavable surfactant for top-down proteomics
por: Brown, Kyle A., et al.
Publicado: (2019)

Top-Down Proteomics and the Challenges of True Proteoform Characterization
por: Po, Allen, et al.
Publicado: (2023)

TopFD: A Proteoform Feature Detection Tool for Top–Down Proteomics
por: Basharat, Abdul Rehman, et al.
Publicado: (2023)

Neutron-Encoded Mass Signatures for Quantitative Top-Down Proteomics∥
por: Rhoads, Timothy W., et al.
Publicado: (2014)

Induced oscillatory signaling in the beta frequency of top-down pain modulation
por: Diers, Martin, et al.
Publicado: (2020)

Super-tough PVC/CPE composites: an efficient CPE network by an MGA copolymer prepared through a vibro-milling process
por: Wang, Tao, et al.
Publicado: (2020)

Strengthening capacity for community and public engagement (CPE): a mixed-methods evaluation of the ‘DELTAS Africa CPE seed fund’ pilot
por: Mwangi, Leah, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_94bpcr9pckdjb99f4mai2d7um3