Effect of itraconazole and fluconazole on the pharmacokinetics of valemetostat: An open‐label, phase I study in healthy subjects

Valemetostat tosylate (valemetostat) is an oral, potent, dual inhibitor of enhancer of zeste homolog (EZH) 2 and EZH1 under investigation for the treatment of cancer, including non‐Hodgkin's lymphomas and solid tumors. Itraconazole and fluconazole are antifungal medications often used as typica...

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Detalles Bibliográficos
Autores principales: Tachibana, Masaya, Matsuki, Shunji, Maekawa, Yutaro, Kuroda, Kana, Shimizu, Takako, Tsutsumi, Junko, Ishizuka, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651645/
https://www.ncbi.nlm.nih.gov/pubmed/37705321
http://dx.doi.org/10.1111/cts.13613

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651645/
https://www.ncbi.nlm.nih.gov/pubmed/37705321
http://dx.doi.org/10.1111/cts.13613

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