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The “One‐Step” approach for QT analysis increases the sensitivity of nonclinical QTc analysis
Whether a compound prolongs cardiac repolarization independent of changes in beat rate is a critical question in drug research and development. Current practice is to resolve this in two steps. First, the QT interval is corrected for the influence of rate and then statistical significance is tested....
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651649/ https://www.ncbi.nlm.nih.gov/pubmed/37726963 http://dx.doi.org/10.1111/cts.13625 |