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The “One‐Step” approach for QT analysis increases the sensitivity of nonclinical QTc analysis

Whether a compound prolongs cardiac repolarization independent of changes in beat rate is a critical question in drug research and development. Current practice is to resolve this in two steps. First, the QT interval is corrected for the influence of rate and then statistical significance is tested....

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Detalles Bibliográficos
Autores principales: Leishman, Derek J., Holdsworth, David L., Lauver, D. Adam, Bailie, Marc B., Roche, Brian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651649/
https://www.ncbi.nlm.nih.gov/pubmed/37726963
http://dx.doi.org/10.1111/cts.13625