Application of a physiologically based pharmacokinetic model to predict isoniazid disposition during pregnancy

Pregnancy can increase the risk of latent tuberculosis infection (LTBI) progression to tuberculosis (TB) disease. Isoniazid (INH) is the preferred preventative treatment for LTBI in pregnancy. INH is mainly cleared by N‐acetyltransferase 2 (NAT2) but the pharmacokinetics (PK) of INH in different NAT...

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Detalles Bibliográficos
Autores principales: Amaeze, Ogochukwu U., Isoherranen, Nina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651660/
https://www.ncbi.nlm.nih.gov/pubmed/37712488
http://dx.doi.org/10.1111/cts.13614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651660/
https://www.ncbi.nlm.nih.gov/pubmed/37712488
http://dx.doi.org/10.1111/cts.13614

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