Cleaner synthesis of preclinically validated vaccine adjuvants

We developed synthetic glycophospholipids based on a glucosamine core (FP compounds) with potent and selective activity in stimulating Toll-Like Receptor 4 (TLR4) as agonists. These compounds have activity and toxicity profiles similar to the clinically approved adjuvant monophosphoryl lipid A (MPLA...

Descripción completa

Detalles Bibliográficos
Autores principales: Romerio, Alessio, Peri, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651716/
https://www.ncbi.nlm.nih.gov/pubmed/38025058
http://dx.doi.org/10.3389/fchem.2023.1252996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651716/
https://www.ncbi.nlm.nih.gov/pubmed/38025058
http://dx.doi.org/10.3389/fchem.2023.1252996

Ejemplares similares