Therapeutic activity of GARP:TGF-β1 blockade in murine primary myelofibrosis

Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by the clonal expansion of myeloid cells, notably megakaryocytes (MKs), and an aberrant cytokine production leading to bone marrow (BM) fibrosis and insufficiency. Current treatment options are limited. TGF-β1, a profibrotic...

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Detalles Bibliográficos
Autores principales: Lecomte, Sara, Devreux, Julien, de Streel, Grégoire, van Baren, Nicolas, Havelange, Violaine, Schröder, David, Vaherto, Noora, Vanhaver, Christophe, Vanderaa, Christophe, Dupuis, Noémie, Pecquet, Christian, Coulie, Pierre G., Constantinescu, Stefan N., Lucas, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Immunobiology and Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651781/
https://www.ncbi.nlm.nih.gov/pubmed/36322928
http://dx.doi.org/10.1182/blood.2022017097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651781/
https://www.ncbi.nlm.nih.gov/pubmed/36322928
http://dx.doi.org/10.1182/blood.2022017097

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