Genetic perturbation of mitochondrial function reveals functional role for specific mitonuclear genes, metabolites, and pathways that regulate lifespan

Altered mitochondrial function is tightly linked to lifespan regulation, but underlying mechanisms remain unclear. Here, we report the chronological and replicative lifespan variation across 167 yeast knock-out strains, each lacking a single nuclear-coded mitochondrial gene, including 144 genes with...

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Detalles Bibliográficos
Autores principales: Phua, Cheryl Zi Jin, Zhao, Xiaqing, Turcios-Hernandez, Lesly, McKernan, Morrigan, Abyadeh, Morteza, Ma, Siming, Promislow, Daniel, Kaeberlein, Matt, Kaya, Alaattin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651825/
https://www.ncbi.nlm.nih.gov/pubmed/37086368
http://dx.doi.org/10.1007/s11357-023-00796-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651825/
https://www.ncbi.nlm.nih.gov/pubmed/37086368
http://dx.doi.org/10.1007/s11357-023-00796-4

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