Secreted mutant calreticulins as rogue cytokines in myeloproliferative neoplasms

Mutant calreticulin (CALR) proteins resulting from a −1/+2 frameshifting mutation of the CALR exon 9 carry a novel C-terminal amino acid sequence and drive the development of myeloproliferative neoplasms (MPNs). Mutant CALRs were shown to interact with and activate the thrombopoietin receptor (TpoR/...

Descripción completa

Detalles Bibliográficos
Autores principales: Pecquet, Christian, Papadopoulos, Nicolas, Balligand, Thomas, Chachoua, Ilyas, Tisserand, Amandine, Vertenoeil, Gaëlle, Nédélec, Audrey, Vertommen, Didier, Roy, Anita, Marty, Caroline, Nivarthi, Harini, Defour, Jean-Philippe, El-Khoury, Mira, Hug, Eva, Majoros, Andrea, Xu, Erica, Zagrijtschuk, Oleh, Fertig, Tudor E., Marta, Daciana S., Gisslinger, Heinz, Gisslinger, Bettina, Schalling, Martin, Casetti, Ilaria, Rumi, Elisa, Pietra, Daniela, Cavalloni, Chiara, Arcaini, Luca, Cazzola, Mario, Komatsu, Norio, Kihara, Yoshihiko, Sunami, Yoshitaka, Edahiro, Yoko, Araki, Marito, Lesyk, Roman, Buxhofer-Ausch, Veronika, Heibl, Sonja, Pasquier, Florence, Havelange, Violaine, Plo, Isabelle, Vainchenker, William, Kralovics, Robert, Constantinescu, Stefan N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Myeloid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651872/
https://www.ncbi.nlm.nih.gov/pubmed/36356299
http://dx.doi.org/10.1182/blood.2022016846

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651872/
https://www.ncbi.nlm.nih.gov/pubmed/36356299
http://dx.doi.org/10.1182/blood.2022016846

Ejemplares similares