Deletion of glutamate carboxypeptidase II (GCPII), but not GCPIII, provided long‐term benefits in mice with traumatic brain injury

MAIN PROBLEM: N‐acetylaspartylglutamate (NAAG) has neuroprotective effects in traumatic brain injury (TBI) by activating metabotropic glutamate receptor 3 (mGluR3) and reducing glutamate release. Glutamate carboxypeptidase II (GCPII) is the primary enzyme responsible for the hydrolysis of NAAG. It r...

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Detalles Bibliográficos
Autores principales: Ji, Tongjie, Pang, Ying, Cheng, Meng, Wang, Rui, Chen, Xu, Zhang, Chunyu, Liu, Min, Zhang, Jing, Zhong, Chunlong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651966/
https://www.ncbi.nlm.nih.gov/pubmed/37349952
http://dx.doi.org/10.1111/cns.14299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651966/
https://www.ncbi.nlm.nih.gov/pubmed/37349952
http://dx.doi.org/10.1111/cns.14299

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