Cargando…

Deletion of glutamate carboxypeptidase II (GCPII), but not GCPIII, provided long‐term benefits in mice with traumatic brain injury

MAIN PROBLEM: N‐acetylaspartylglutamate (NAAG) has neuroprotective effects in traumatic brain injury (TBI) by activating metabotropic glutamate receptor 3 (mGluR3) and reducing glutamate release. Glutamate carboxypeptidase II (GCPII) is the primary enzyme responsible for the hydrolysis of NAAG. It r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ji, Tongjie, Pang, Ying, Cheng, Meng, Wang, Rui, Chen, Xu, Zhang, Chunyu, Liu, Min, Zhang, Jing, Zhong, Chunlong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651966/ https://www.ncbi.nlm.nih.gov/pubmed/37349952 http://dx.doi.org/10.1111/cns.14299

Ejemplares similares

Mouse glutamate carboxypeptidase II (GCPII) has a similar enzyme activity and inhibition profile but a different tissue distribution to human GCPII
por: Knedlík, Tomáš, et al.
Publicado: (2017)

Chronic GCPII (glutamate‐carboxypeptidase‐II) inhibition reduces pT217Tau levels in the entorhinal and dorsolateral prefrontal cortices of aged macaques
por: Bathla, Shveta, et al.
Publicado: (2023)

Glutamate carboxypeptidase II gene knockout attenuates oxidative stress and cortical apoptosis after traumatic brain injury
por: Cao, Yang, et al.
Publicado: (2016)

Metabolite differences between glutamate carboxypeptidase II gene knockout mice and their wild-type littermates after traumatic brain injury: a 7-tesla (1)H-MRS study
por: Wu, Wenbo, et al.
Publicado: (2018)

mNSCs overexpressing Rimkla transplantation facilitates cognitive recovery in a mouse model of traumatic brain injury
por: Ji, Tongjie, et al.
Publicado: (2023)

CARBOXYPEPTIDASE : II. THE PARTIAL PURIFICATION OF PRO-CARBOXYPEPTIDASE
por: Anson, M. L.
Publicado: (1937)

Characterization of glutamate carboxypeptidase 2 orthologs in trematodes
por: Jedlickova, Lucie, et al.
Publicado: (2022)

Combination of In Silico and In Vitro Screening to Identify Novel Glutamate Carboxypeptidase II Inhibitors
por: Temml, Veronika, et al.
Publicado: (2023)

Glutamate Carboxypeptidase II Inhibition Behaviorally and Physiologically Improves Pyridoxine-Induced Neuropathy in Rats
por: Potter, Michelle C., et al.
Publicado: (2014)

Glutamate Carboxypeptidase II in Aging Rat Prefrontal Cortex Impairs Working Memory Performance
por: Datta, Dibyadeep, et al.
Publicado: (2021)

D-DOPA Is a Potent, Orally Bioavailable, Allosteric Inhibitor of Glutamate Carboxypeptidase II
por: Gori, Sadakatali S., et al.
Publicado: (2022)

Expression of glutamate carboxypeptidase II in the glial tumor recurrence evaluated in vivo using radionuclide imaging
por: Kunikowska, Jolanta, et al.
Publicado: (2022)

CARBOXYPEPTIDASE : III. THE ESTIMATION OF CARBOXYPEPTIDASE AND PRO-CARBOXYPEPTIDASE
por: Anson, M. L.
Publicado: (1937)

Dendrimer-Conjugated Glutamate Carboxypeptidase II Inhibitor Restores Microglial Changes in a Rabbit Model of Cerebral Palsy
por: Sah, Nirnath, et al.
Publicado: (2023)

Inhibition of glutamate-carboxypeptidase-II in dorsolateral prefrontal cortex: potential therapeutic target for neuroinflammatory cognitive disorders
por: Yang, Shengtao, et al.
Publicado: (2022)

Plasma glutamate carboxypeptidase is a negative regulator in liver cancer metastasis
por: Lee, Jae-Hye, et al.
Publicado: (2016)

The Chromatin Remodeler ATRX: Role and Mechanism in Biology and Cancer
por: Pang, Ying, et al.
Publicado: (2023)

CARBOXYPEPTIDASE : I. THE PREPARATION OF CRYSTALLINE CARBOXYPEPTIDASE
por: Anson, M. L.
Publicado: (1937)

A role for the locus coeruleus in the analgesic efficacy of N-acetylaspartylglutamate peptidase (GCPII) inhibitors ZJ43 and 2-PMPA
por: Nonaka, Takahiro, et al.
Publicado: (2017)

Glutamate carboxypeptidase activity in human skin biopsies as a pharmacodynamic marker for clinical studies
por: Rojas, Camilo, et al.
Publicado: (2011)

In vivo Molecular Imaging of Glutamate Carboxypeptidase II Expression in Re-endothelialisation after Percutaneous Balloon Denudation in a Rat Model
por: Endepols, Heike, et al.
Publicado: (2018)

Dendrimer-2PMPA selectively blocks upregulated microglial GCPII activity and improves cognition in a mouse model of multiple sclerosis
por: Hollinger, Kristen R., et al.
Publicado: (2022)

Comparison of Substrate Specificity of Escherichia Coli p-Aminobenzoyl-Glutamate Hydrolase with Pseudomonas Carboxypeptidase G
por: Larimer, Cassandra M., et al.
Publicado: (2014)

Peptidoglycan ld-Carboxypeptidase Pgp2 Influences Campylobacter jejuni Helical Cell Shape and Pathogenic Properties and Provides the Substrate for the dl-Carboxypeptidase Pgp1
por: Frirdich, Emilisa, et al.
Publicado: (2014)

Life without glutamate: the epigenetic effects of glutamate deletion
por: Edelstein, Lawrence, et al.
Publicado: (2014)

Two Sides of Quantum-Based Modeling of Enzyme-Catalyzed Reactions: Mechanistic and Electronic Structure Aspects of the Hydrolysis by Glutamate Carboxypeptidase
por: Krivitskaya, Alexandra V., et al.
Publicado: (2021)

Neuroprotective effects of a dendrimer-based glutamate carboxypeptidase inhibitor on superoxide dismutase transgenic mice after neonatal hypoxic-ischemic brain injury
por: Cabeza, O. Arteaga, et al.
Publicado: (2020)

A Fluorometric Method of Measuring Carboxypeptidase Activities for Angiotensin II and Apelin-13
por: Liu, Pan, et al.
Publicado: (2017)

Regulation of dopamine transporter activity by carboxypeptidase E
por: Zhang, Heping, et al.
Publicado: (2009)

Carboxypeptidase E-ΔN, a Neuroprotein Transiently Expressed during Development Protects Embryonic Neurons against Glutamate Neurotoxicity
por: Qin, Xiao-Yan, et al.
Publicado: (2014)

Measurement of carboxypeptidase R by colorimetric assay
por: Komura, H, et al.
Publicado: (2002)

Regulation of Chemerin Bioactivity by Plasma Carboxypeptidase N, Carboxypeptidase B (Activated Thrombin-activable Fibrinolysis Inhibitor), and Platelets
por: Du, Xiao-Yan, et al.
Publicado: (2009)

HIF-1α-Dependent Induction of Carboxypeptidase A4 and Carboxypeptidase E in Hypoxic Human Adipose-Derived Stem Cells
por: Moon, Yunwon, et al.
Publicado: (2020)

Ambivalent roles of carboxypeptidase B in the lytic susceptibility of fibrin()
por: Kovács, András, et al.
Publicado: (2014)

Role of Cytosolic Carboxypeptidase 5 in Neuronal Survival and Spermatogenesis
por: Wu, Hui-Yuan, et al.
Publicado: (2017)

Prognostic significance of carboxypeptidase Q and its methylation in glioblastoma
por: Liu, Qiaodan, et al.
Publicado: (2023)

Gene dosage-dependent secretion of yeast vacuolar carboxypeptidase Y
Publicado: (1986)

Engineering an efficient secretion of leech carboxypeptidase inhibitor in Escherichia coli
por: Puertas, Juan-Miguel, et al.
Publicado: (2009)

The Expression of Hepatic Carboxypeptidase E is Decreased in Patients with Cholesterol Gallstone
por: Dai, Shu-Long, et al.
Publicado: (2015)

Characterization of putative DD-carboxypeptidase-encoding genes in Mycobacterium smegmatis
por: Ealand, Christopher S., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_os89qj01k6pm2pkj7u12mv9d04