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Cdk5 phosphorylation‐dependent C9orf72 degradation promotes neuronal death in Parkinson's disease models

AIMS: Chromosome 9 open reading frame 72 (C9orf72) is one of the most dazzling molecules in neurodegenerative diseases, albeit that its role in Parkinson's disease (PD) remains unknown. This article aimed to explore the potential mechanism of C9orf72 involved in the pathogenesis of PD. METHODS:...

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Detalles Bibliográficos
Autores principales: Xu, Xingfeng, Li, Mao, Su, Yan, Wang, Qi, Qin, Peifang, Huang, Haitao, Zhang, Yuting, Zhou, Yali, Yan, Jianguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10651984/
https://www.ncbi.nlm.nih.gov/pubmed/37353944
http://dx.doi.org/10.1111/cns.14319