Proenkephalin deletion in hematopoietic cells induces intestinal barrier failure resulting in clinical feature similarities with irritable bowel syndrome in mice

Opioid-dependent immune-mediated analgesic effects have been broadly reported upon inflammation. In preclinical mouse models of intestinal inflammatory diseases, the local release of enkephalins (endogenous opioids) by colitogenic T lymphocytes alleviate inflammation-induced pain by down-modulating...

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Detalles Bibliográficos
Autores principales: Mas-Orea, Xavier, Rey, Lea, Battut, Louise, Bories, Cyrielle, Petitfils, Camille, Abot, Anne, Gheziel, Nadine, Wemelle, Eve, Blanpied, Catherine, Motta, Jean-Paul, Knauf, Claude, Barreau, Frederick, Espinosa, Eric, Aloulou, Meryem, Cenac, Nicolas, Serino, Matteo, Mouledous, Lionel, Fazilleau, Nicolas, Dietrich, Gilles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652007/
https://www.ncbi.nlm.nih.gov/pubmed/37968381
http://dx.doi.org/10.1038/s42003-023-05542-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652007/
https://www.ncbi.nlm.nih.gov/pubmed/37968381
http://dx.doi.org/10.1038/s42003-023-05542-2

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