Cargando…

STAT3 modulates CD4 (+) T mitochondrial dynamics and function in aging

Aging promotes numerous intracellular changes in T cells that impact their effector function. Our data show that aging promotes an increase in the localization of STAT3 to the mitochondria (mitoSTAT3), which promotes changes in mitochondrial dynamics and function and T‐cell cytokine production. Mech...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zukowski, Emelia, Sannella, Marco, Rockhold, Jack Donato, Kalantar, Gabriella H., Yu, Jingting, SantaCruz‐Calvo, Sara, Kuhn, Madison K., Hah, Nasun, Ouyang, Ling, Wang, Tzu‐Wen, Murphy, Lyanne, Marszalkowski, Heather, Gibney, Kaleigh, Drummond, Micah J., Proctor, Elizabeth A., Hasturk, Hatice, Nikolajczyk, Barbara S., Bharath, Leena P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652300/ https://www.ncbi.nlm.nih.gov/pubmed/37837188 http://dx.doi.org/10.1111/acel.13996

Ejemplares similares

Obesity and Fatty Acids Promote Mitochondrial Translocation of STAT3 Through ROS-Dependent Mechanisms
por: Conway, Rachel, et al.
Publicado: (2022)

Saturated Fatty Acid Activates T Cell Inflammation Through a Nicotinamide Nucleotide Transhydrogenase (NNT)-Dependent Mechanism
por: McCambridge, Grace, et al.
Publicado: (2019)

Commentary on Camell et al., Aging Induces Nlrp3 Inflammasome Dependent Adipose B Cell Expansion to Impair Metabolic Homeostasis
por: SantaCruz-Calvo, Sara, et al.
Publicado: (2020)

Selective Autophagy in Hyperglycemia-Induced Microvascular and Macrovascular Diseases
por: Bharath, Leena P., et al.
Publicado: (2021)

Editorial: “Obesity, Metabolism and the immune system”
por: Frasca, Daniela, et al.
Publicado: (2022)

Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation
por: Bharath, Leena P., et al.
Publicado: (2020)

Enhancer transcripts mark active estrogen receptor binding sites
por: Hah, Nasun, et al.
Publicado: (2013)

Microglia use TAM receptors to detect and engulf amyloid beta plaques
por: Huang, Youtong, et al.
Publicado: (2021)

Oral Inflammatory Diseases and Systemic Inflammation: Role of the Macrophage
por: Hasturk, Hatice, et al.
Publicado: (2012)

BRD9 regulates interferon-stimulated genes during macrophage activation via cooperation with BET protein BRD4
por: Ahmed, Nasiha S., et al.
Publicado: (2021)

Annual alveolar bone loss in subjects with cardiovascular disease adjusting for associated systemic diseases and risk factors: a retrospective study
por: Helmi, Mohammad, et al.
Publicado: (2020)

Rapid specific detection of oral bacteria using Cas13-based SHERLOCK
por: Liu, Jett, et al.
Publicado: (2023)

Tissue Immune Cells Fuel Obesity-Associated Inflammation in Adipose Tissue and Beyond
por: Liu, Rui, et al.
Publicado: (2019)

The Effect of Testicular Extract on the Distribution and Absorption of Subcutaneous Saline Solution
por: Sannella, Lee S.
Publicado: (1940)

The Bidirectional Relationship between Metabolism and Immune Responses
por: Raval, Forum M., et al.
Publicado: (2013)

Annual alveolar bone loss in older adults taking oral bisphosphonate: a retrospective cohort study
por: Helmi, Mohammad, et al.
Publicado: (2019)

Prevalence of periodontitis and alveolar bone loss in a patient population at Harvard School of Dental Medicine
por: Helmi, Mohammad F., et al.
Publicado: (2019)

Resolvin E1 Regulates Th17 Function and T Cell Activation
por: Oner, Fatma, et al.
Publicado: (2021)

Periodontal Disease, Local and Systemic Inflammation in Puerto Ricans with Type 2 Diabetes Mellitus
por: Andriankaja, Oelisoa M., et al.
Publicado: (2023)

Dysregulation of Systemic Immunity in Aging and Dementia
por: Lutshumba, Jenny, et al.
Publicado: (2021)

Differential responses of primary neuron-secreted MCP-1 and IL-9 to type 2 diabetes and Alzheimer’s disease-associated metabolites
por: Ball, Brendan K., et al.
Publicado: (2023)

Arthrobacter siccitolerans sp. nov., a highly desiccation-tolerant, xeroprotectant-producing strain isolated from dry soil
por: SantaCruz-Calvo, L., et al.
Publicado: (2013)

Comparative study on tertiary contacts and folding of RNase P RNAs from a psychrophilic, a mesophilic/radiation-resistant, and a thermophilic bacterium
por: Marszalkowski, Michal, et al.
Publicado: (2021)

Impaired host response and the presence of Acinetobacter baumannii in the serum microbiome of type-II diabetic patients
por: Perera, Dasith, et al.
Publicado: (2020)

Impaired Phagocytosis in Localized Aggressive Periodontitis: Rescue by Resolvin E1
por: Fredman, Gabrielle, et al.
Publicado: (2011)

Transcriptomics of type 2 diabetic and healthy human neutrophils
por: Kleinstein, Sarah E., et al.
Publicado: (2021)

The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages
por: Daniel, Bence, et al.
Publicado: (2014)

Uncovering Factors Related to Pancreatic Beta-Cell Function
por: Curran, Aoife M., et al.
Publicado: (2016)

Clinical Trials Registration
por: Rockhold, Frank W, et al.
Publicado: (2006)

Open Science to Address COVID-19: Sharing Data to Make Our Research Investment Go Further
por: Zariffa, Névine, et al.
Publicado: (2020)

The hidden ‘mycobacteriome’ of the human healthy oral cavity and upper respiratory tract
por: Macovei, Lilia, et al.
Publicado: (2015)

PGC-1α-Targeted Therapeutic Approaches to Enhance Muscle Recovery in Aging
por: Petrocelli, Jonathan J., et al.
Publicado: (2020)

Editorial: Insights in aging and the immune system: 2021
por: Haynes, Laura, et al.
Publicado: (2022)

Mathematical foundations of computer science 2015: 40th international symposium, MFCS 2015, Milan, Italy, August 24-28, 2015, proceedings, part II
por: Italiano, Giuseppe F, et al.
Publicado: (2015)

Alzheimer’s disease-specific cytokine secretion suppresses neuronal mitochondrial metabolism
por: Kuhn, Madison K., et al.
Publicado: (2023)

Amyloid-β Pathology-Specific Cytokine Secretion Suppresses Neuronal Mitochondrial Metabolism
por: Kuhn, Madison K., et al.
Publicado: (2023)

Hypoxia‐induced endothelial cell responses – possible roles during periodontal disease
por: Mendes, Reila T., et al.
Publicado: (2018)

Dental plaque microbial profiles of children from Khartoum, Sudan, with congenital heart defects
por: Mohamed Ali, Hiba, et al.
Publicado: (2017)

Investigation of boron adsorption by graphene oxide: equilibrium, kinetic, and thermodynamic studies
por: ÖNEN, Mehmet Fatih, et al.
Publicado: (2023)

Maresin-1 and Resolvin E1 Promote Regenerative Properties of Periodontal Ligament Stem Cells Under Inflammatory Conditions
por: Albuquerque-Souza, Emmanuel, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_bpm969bjkd1ajl72977r0km8gi