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IL‐21‐IgFc immunotherapy alters transcriptional landscape of lymph node cells leading to enhanced flu vaccine response in aging and SIV infection

Aging people living with HIV (PWH) frequently manifest impaired antibody (Ab) responses to seasonal flu vaccination which has been attributed to ongoing inflammation and immune activation. We have recently reported a similar scenario in old simian immunodeficiency virus (SIV) infected rhesus macaque...

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Detalles Bibliográficos
Autores principales: Pallikkuth, Suresh, Kvistad, Daniel, Sirupangi, Tirupataiah, Kizhner, Alexander, Pahwa, Rajendra, Cameron, Mark J., Richardson, Brian, Williams, Sion, Ayupe, Ana, Brooks, Marissa, Petrovas, Constantinos, Villinger, Francois, Pahwa, Savita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652303/
https://www.ncbi.nlm.nih.gov/pubmed/37712598
http://dx.doi.org/10.1111/acel.13984