Senolytics prevent caveolar Ca(V)3.2‐RyR axis malfunction in old vascular smooth muscle

Aging is a major risk factor for cardiovascular diseases. Our previous studies demonstrate that aging impairs the caveolar T‐type Ca(V)3.2‐RyR axis for extracellular Ca(2+) influx to trigger Ca(2+) sparks in vascular smooth muscle cells (VSMCs). We hypothesize that the administration of senolytics,...

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Detalles Bibliográficos
Autores principales: Lin, Jie, Guo, Weiming, Luo, Qingtian, Zhang, Qingping, Wan, Teng, Jiang, Changyu, Ye, Yuanchun, Lin, Haihuan, Fan, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652315/
https://www.ncbi.nlm.nih.gov/pubmed/37837625
http://dx.doi.org/10.1111/acel.14002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652315/
https://www.ncbi.nlm.nih.gov/pubmed/37837625
http://dx.doi.org/10.1111/acel.14002

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