Insulin resistance induces earlier initiation of cognitive dysfunction mediated by cholinergic deregulation in a mouse model of Alzheimer's disease

Although insulin resistance increases the risk of Alzheimer's disease (AD), the mechanisms remain unclear, partly because no animal model exhibits the insulin‐resistant phenotype without persistent hyperglycemia. Here we established an AD model with whole‐body insulin resistance without persist...

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Detalles Bibliográficos
Autores principales: Izuo, Naotaka, Watanabe, Nobuhiro, Noda, Yoshihiro, Saito, Takashi, Saido, Takaomi C., Yokote, Koutaro, Hotta, Harumi, Shimizu, Takahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652326/
https://www.ncbi.nlm.nih.gov/pubmed/37822109
http://dx.doi.org/10.1111/acel.13994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652326/
https://www.ncbi.nlm.nih.gov/pubmed/37822109
http://dx.doi.org/10.1111/acel.13994

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