Cargando…

Insulin resistance induces earlier initiation of cognitive dysfunction mediated by cholinergic deregulation in a mouse model of Alzheimer's disease

Although insulin resistance increases the risk of Alzheimer's disease (AD), the mechanisms remain unclear, partly because no animal model exhibits the insulin‐resistant phenotype without persistent hyperglycemia. Here we established an AD model with whole‐body insulin resistance without persist...

Descripción completa

Detalles Bibliográficos
Autores principales:	Izuo, Naotaka, Watanabe, Nobuhiro, Noda, Yoshihiro, Saito, Takashi, Saido, Takaomi C., Yokote, Koutaro, Hotta, Harumi, Shimizu, Takahiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652326/ https://www.ncbi.nlm.nih.gov/pubmed/37822109 http://dx.doi.org/10.1111/acel.13994

Ejemplares similares

Superoxide Dismutase 1 Loss Disturbs Intracellular Redox Signaling, Resulting in Global Age-Related Pathological Changes
por: Watanabe, Kenji, et al.
Publicado: (2014)

Palladium and Platinum Nanoparticles Attenuate Aging-Like Skin Atrophy via Antioxidant Activity in Mice
por: Shibuya, Shuichi, et al.
Publicado: (2014)

A Toxic Conformer of Aβ42 with a Turn at 22–23 is a Novel Therapeutic Target for Alzheimer’s Disease
por: Izuo, Naotaka, et al.
Publicado: (2017)

Resveratrol Derivative-Rich Melinjo Seed Extract Attenuates Skin Atrophy in Sod1-Deficient Mice
por: Watanabe, Kenji, et al.
Publicado: (2015)

Brain-Specific Superoxide Dismutase 2 Deficiency Causes Perinatal Death with Spongiform Encephalopathy in Mice
por: Izuo, Naotaka, et al.
Publicado: (2015)

Neuroinflammation in mouse models of Alzheimer's disease
por: Saito, Takashi, et al.
Publicado: (2018)

Detection of Amyloid β Oligomers with RNA Aptamers in App(NL-G-F/NL-G-F) Mice: A Model of Arctic Alzheimer’s Disease
por: Obata, Yayoi, et al.
Publicado: (2020)

Topical Application of Trisodium Ascorbyl 6-Palmitate 2-Phosphate Actively Supplies Ascorbate to Skin Cells in an Ascorbate Transporter-Independent Manner
por: Shibuya, Shuichi, et al.
Publicado: (2017)

Metabolism of amyloid β peptide and pathogenesis of Alzheimer’s disease
por: SAIDO, Takaomi C.
Publicado: (2013)

APP Knock-In Mice Produce E22P-Aβ Exhibiting an Alzheimer’s Disease-like Phenotype with Dysregulation of Hypoxia-Inducible Factor Expression
por: Maki, Takahito, et al.
Publicado: (2022)

Is obesity an absolute evil? Increase in adipose tissue does not always decrease insulin sensitivity
por: Ishikawa, Ko, et al.
Publicado: (2014)

Sod1 Loss Induces Intrinsic Superoxide Accumulation Leading to p53-Mediated Growth Arrest and Apoptosis
por: Watanabe, Kenji, et al.
Publicado: (2013)

Gentle Mechanical Skin Stimulation Inhibits Micturition Contractions via the Spinal Opioidergic System and by Decreasing Both Ascending and Descending Transmissions of the Micturition Reflex in the Spinal Cord
por: Hotta, Harumi, et al.
Publicado: (2015)

Heart Rate Changes in Response to Mechanical Pressure Stimulation of Skeletal Muscles Are Mediated by Cardiac Sympathetic Nerve Activity
por: Watanabe, Nobuhiro, et al.
Publicado: (2017)

Presubiculum principal cells are preserved from degeneration in knock-in APP/TAU mouse models of Alzheimer’s disease
por: Islam, Anam, et al.
Publicado: (2023)

Analysis of Taste Sensitivities in App Knock-In Mouse Model of Alzheimer’s Disease
por: Narukawa, Masataka, et al.
Publicado: (2020)

Critical review: involvement of endoplasmic reticulum stress in the aetiology of Alzheimer's disease
por: Hashimoto, Shoko, et al.
Publicado: (2018)

Dual roles for autophagy: Degradation and secretion of Alzheimer's disease Aβ peptide
por: Nilsson, Per, et al.
Publicado: (2014)

Time to consider an Asian guideline for management of dyslipidemia?
por: Yokote, Koutaro, et al.
Publicado: (2012)

Novel Quantitative Analyses of Spontaneous Synaptic Events in Cortical Pyramidal Cells Reveal Subtle Parvalbumin-Expressing Interneuron Dysfunction in a Knock-In Mouse Model of Alzheimer’s Disease
por: Chen, Lingxuan, et al.
Publicado: (2018)

Types of skin afferent fibers and spinal opioid receptors that contribute to touch-induced inhibition of heart rate changes evoked by noxious cutaneous heat stimulation
por: Watanabe, Nobuhiro, et al.
Publicado: (2015)

Influence of Intragastric Administration of Traditional Japanese Medicine, Ninjin'Yoeito, on Cerebral Blood Flow via Muscarinic Acetylcholine Receptors
por: Watanabe, Nobuhiro, et al.
Publicado: (2021)

Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer’s disease diagnosis
por: Murakami, Kazuma, et al.
Publicado: (2016)

New Insights Regarding Diagnosis and Medication for Schizophrenia Based on Neuronal Synapse–Microglia Interaction
por: Izuo, Naotaka, et al.
Publicado: (2021)

Microglia and CD206(+) border-associated mouse macrophages maintain their embryonic origin during Alzheimer’s disease
por: Wu, Xiaoting, et al.
Publicado: (2021)

Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer’s disease
por: Sakakibara, Yasufumi, et al.
Publicado: (2019)

Lysine-targeting inhibition of amyloid β oligomerization by a green perilla-derived metastable chalcone in vitro and in vivo
por: Murakami, Kazuma, et al.
Publicado: (2022)

Age-Related Changes in Neuromodulatory Control of Bladder Micturition Contractions Originating in the Skin
por: Hotta, Harumi, et al.
Publicado: (2018)

Vascular Gap Junctions Contribute to Forepaw Stimulation-Induced Vasodilation Differentially in the Pial and Penetrating Arteries in Isoflurane-Anesthetized Rats
por: Watanabe, Nobuhiro, et al.
Publicado: (2018)

Presenilin-2 Mutation Causes Early Amyloid Accumulation and Memory Impairment in a Transgenic Mouse Model of Alzheimer's Disease
por: Toda, Toshihiko, et al.
Publicado: (2011)

Aptamers targeting amyloidogenic proteins and their emerging role in neurodegenerative diseases
por: Murakami, Kazuma, et al.
Publicado: (2021)

Increased neutrophils in inflammatory bowel disease accelerate the accumulation of amyloid plaques in the mouse model of Alzheimer’s disease
por: Kaneko, Ryusei, et al.
Publicado: (2023)

CRISPR/dCas9-Dnmt3a-mediated targeted DNA methylation of APP rescues brain pathology in a mouse model of Alzheimer’s disease
por: Park, Hanseul, et al.
Publicado: (2022)

Proteomic alterations in the brain and blood–brain barrier during brain Aβ accumulation in an APP knock-in mouse model of Alzheimer’s disease
por: Ito, Shingo, et al.
Publicado: (2023)

Early Identification of Alzheimer's Disease in Mouse Models: Application of Deep Neural Network Algorithm to Cognitive Behavioral Parameters
por: Sutoko, Stephanie, et al.
Publicado: (2021)

Ceritinib Aggravates Glycemic Control in Insulin-treated Patients with Diabetes and Metastatic ALK-positive Lung Cancer
por: Sakuma, Ikki, et al.
Publicado: (2018)

Biomarkers for Alzheimer's disease: Earlier, easier, and fairer
por: eBioMedicine
Publicado: (2022)

Hippocampal neural circuit connectivity alterations in an Alzheimer’s disease mouse model revealed by monosynaptic rabies virus tracing
por: Ye, Qiao, et al.
Publicado: (2022)

Impaired In Vivo Gamma Oscillations in the Medial Entorhinal Cortex of Knock-in Alzheimer Model
por: Nakazono, Tomoaki, et al.
Publicado: (2017)

Amelioration of Alzheimer’s Disease by Gut-Pancreas-Liver-Brain Interaction in an App Knock-In Mouse Model
por: Minamisawa, Mayumi, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_fhjpeokf0ajf3vnjs84e31nd5m