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Proteostasis and neurodegeneration: a closer look at autophagy in Alzheimer's disease
Alzheimer's disease (AD) is characterized by the accumulation of misfolded amyloid-beta and tau proteins. Autophagy acts as a proteostasis process to remove protein clumps, although it progressively weakens with aging and AD, thus facilitating the accumulation of toxic proteins and causing neur...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652403/ https://www.ncbi.nlm.nih.gov/pubmed/38020769 http://dx.doi.org/10.3389/fnagi.2023.1281338 |
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author | Barmaki, Haleh Nourazarian, Alireza Khaki-Khatibi, Fatemeh |
author_facet | Barmaki, Haleh Nourazarian, Alireza Khaki-Khatibi, Fatemeh |
author_sort | Barmaki, Haleh |
collection | PubMed |
description | Alzheimer's disease (AD) is characterized by the accumulation of misfolded amyloid-beta and tau proteins. Autophagy acts as a proteostasis process to remove protein clumps, although it progressively weakens with aging and AD, thus facilitating the accumulation of toxic proteins and causing neurodegeneration. This review examines the impact of impaired autophagy on the progression of AD disease pathology. Under normal circumstances, autophagy removes abnormal proteins and damaged organelles, but any dysfunction in this process can lead to the exacerbation of amyloid and tau pathology, particularly in AD. There is increasing attention to therapeutic tactics to revitalize autophagy, including reduced caloric intake, autophagy-stimulating drugs, and genetic therapy. However, the translation of these strategies into clinical practice faces several hurdles. In summary, this review integrates the understanding of the intricate role of autophagy dysfunction in Alzheimer's disease progression and reinforces the promising prospects of autophagy as a beneficial target for treatments to modify the course of Alzheimer's disease. |
format | Online Article Text |
id | pubmed-10652403 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106524032023-01-01 Proteostasis and neurodegeneration: a closer look at autophagy in Alzheimer's disease Barmaki, Haleh Nourazarian, Alireza Khaki-Khatibi, Fatemeh Front Aging Neurosci Aging Neuroscience Alzheimer's disease (AD) is characterized by the accumulation of misfolded amyloid-beta and tau proteins. Autophagy acts as a proteostasis process to remove protein clumps, although it progressively weakens with aging and AD, thus facilitating the accumulation of toxic proteins and causing neurodegeneration. This review examines the impact of impaired autophagy on the progression of AD disease pathology. Under normal circumstances, autophagy removes abnormal proteins and damaged organelles, but any dysfunction in this process can lead to the exacerbation of amyloid and tau pathology, particularly in AD. There is increasing attention to therapeutic tactics to revitalize autophagy, including reduced caloric intake, autophagy-stimulating drugs, and genetic therapy. However, the translation of these strategies into clinical practice faces several hurdles. In summary, this review integrates the understanding of the intricate role of autophagy dysfunction in Alzheimer's disease progression and reinforces the promising prospects of autophagy as a beneficial target for treatments to modify the course of Alzheimer's disease. Frontiers Media S.A. 2023-11-02 /pmc/articles/PMC10652403/ /pubmed/38020769 http://dx.doi.org/10.3389/fnagi.2023.1281338 Text en Copyright © 2023 Barmaki, Nourazarian and Khaki-Khatibi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Aging Neuroscience Barmaki, Haleh Nourazarian, Alireza Khaki-Khatibi, Fatemeh Proteostasis and neurodegeneration: a closer look at autophagy in Alzheimer's disease |
title | Proteostasis and neurodegeneration: a closer look at autophagy in Alzheimer's disease |
title_full | Proteostasis and neurodegeneration: a closer look at autophagy in Alzheimer's disease |
title_fullStr | Proteostasis and neurodegeneration: a closer look at autophagy in Alzheimer's disease |
title_full_unstemmed | Proteostasis and neurodegeneration: a closer look at autophagy in Alzheimer's disease |
title_short | Proteostasis and neurodegeneration: a closer look at autophagy in Alzheimer's disease |
title_sort | proteostasis and neurodegeneration: a closer look at autophagy in alzheimer's disease |
topic | Aging Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652403/ https://www.ncbi.nlm.nih.gov/pubmed/38020769 http://dx.doi.org/10.3389/fnagi.2023.1281338 |
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