Cargando…

What exactly does the PfK13 C580Y mutation in Plasmodium falciparum influence?

BACKGROUND: The emergence and spread of artemisinin resistance threaten global malaria control and elimination goals, and encourage research on the mechanisms of drug resistance in malaria parasites. Mutations in Plasmodium falciparum Kelch 13 (PfK13) protein are associated with artemisinin resistan...

Descripción completa

Detalles Bibliográficos
Autores principales:	Si, Wenwen, Zhao, Yuemeng, Qin, Xixi, Huang, Yixuan, Yu, Jing, Liu, Xiao, Li, Yanna, Yan, Xiaoli, Zhang, Qingfeng, Sun, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652512/ https://www.ncbi.nlm.nih.gov/pubmed/37974285 http://dx.doi.org/10.1186/s13071-023-06024-4

Ejemplares similares

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance
por: O'Neill, Paul M., et al.
Publicado: (2017)

Novel pfk13 polymorphisms in Plasmodium falciparum population in Ghana
por: Matrevi, Sena Adzoa, et al.
Publicado: (2022)

Reduction in Plasmodium falciparum Pfk13 and pfg377 allele diversity through time in southern Vietnam
por: Thieu, Nguyen Quang, et al.
Publicado: (2022)

Evidence for linkage of pfmdr1, pfcrt, and pfk13 polymorphisms to lumefantrine and mefloquine susceptibilities in a Plasmodium falciparum cross
por: Windle, Sean T., et al.
Publicado: (2020)

Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea
por: Miotto, Olivo, et al.
Publicado: (2020)

pfk13-Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom
por: Sutherland, Colin J., et al.
Publicado: (2017)

Molecular surveillance of pfcrt, pfmdr1 and pfk13-propeller mutations in Plasmodium falciparum isolates imported from Africa to China
por: Huang, Fang, et al.
Publicado: (2021)

Genetic background and PfKelch13 affect artemisinin susceptibility of PfCoronin mutants in Plasmodium falciparum
por: Sharma, Aabha I., et al.
Publicado: (2020)

Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance
por: Mathieu, Luana C, et al.
Publicado: (2020)

Genetic association between the Pfk13 gene mutation and artemisinin resistance phenotype in Plasmodium falciparum isolates from Yunnan Province, China
por: Dong, Ying, et al.
Publicado: (2018)

An innovative diagnostic technology for the codon mutation C580Y in kelch13 of Plasmodium falciparum with MinION nanopore sequencer
por: Imai, Kazuo, et al.
Publicado: (2018)

Molecular surveillance of anti-malarial resistance pfcrt, pfmdr1, and pfk13 polymorphisms in African Plasmodium falciparum imported parasites to Wuhan, China
por: Cheng, Weijia, et al.
Publicado: (2021)

Molecular surveillance of artemisinin resistance-related Pfk13 and pfcrt polymorphisms in imported Plasmodium falciparum isolates reported in eastern China from 2015 to 2019
por: Kong, Xiangli, et al.
Publicado: (2022)

Monitoring PfMDR1 transport in Plasmodium falciparum
por: Reiling, Sarah J, et al.
Publicado: (2015)

Plasmodium falciparum Multidrug Resistance Proteins (pfMRPs)
por: Gil, José Pedro, et al.
Publicado: (2021)

Structure of the Pf12 and Pf41 heterodimeric complex of Plasmodium falciparum 6-cysteine proteins
por: Dietrich, Melanie H, et al.
Publicado: (2022)

Increase in the proportion of Plasmodium falciparum with kelch13 C580Y mutation and decline in pfcrt and pfmdr1 mutant alleles in Papua New Guinea
por: Yoshida, Naoko, et al.
Publicado: (2021)

Structure and Drug Resistance of the Plasmodium falciparum Transporter PfCRT
por: Kim, Jonathan, et al.
Publicado: (2019)

Analysis of structure and function of the giant protein Pf332 in Plasmodium falciparum
por: Hodder, Anthony N, et al.
Publicado: (2008)

Progress with Plasmodium falciparum sporozoite (PfSPZ)-based malaria vaccines
por: Richie, Thomas L., et al.
Publicado: (2015)

PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum
por: Kumar, Sudhir, et al.
Publicado: (2017)

PfMFR3: A Multidrug-Resistant Modulator in Plasmodium falciparum
por: Rocamora, Frances, et al.
Publicado: (2021)

Optimization of CRISPR/Cas System for Improving Genome Editing Efficiency in Plasmodium falciparum
por: Zhao, Yuemeng, et al.
Publicado: (2021)

Prevalence of pfk13 and pfmdr1 polymorphisms in Bounkiling, Southern Senegal
por: Ahouidi, Ambroise, et al.
Publicado: (2021)

Identification of Immunodominant Responses to the Plasmodium falciparum Antigens PfUIS3, PfLSA1 and PfLSAP2 in Multiple Strains of Mice
por: Longley, Rhea J., et al.
Publicado: (2015)

Crystal structure of the aquaglyceroporin PfAQP from the malarial parasite Plasmodium falciparum
por: Newby, Zachary E R, et al.
Publicado: (2008)

Initial Characterization of the Pf-Int Recombinase from the Malaria Parasite Plasmodium falciparum
por: Ghorbal, Mehdi, et al.
Publicado: (2012)

Molecular dynamics simulations of PfAQP from the malarial parasite Plasmodium falciparum
por: CUI, YUBAO, et al.
Publicado: (2012)

Specific phosphorylation of the PfRh2b invasion ligand of Plasmodium falciparum
por: Engelberg, Klemens, et al.
Publicado: (2013)

PfMAP-2 is essential for male gametogenesis in the malaria parasite Plasmodium falciparum
por: Hitz, Eva, et al.
Publicado: (2020)

PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparum
por: Jiang, Lubin, et al.
Publicado: (2013)

Assessment of Plasmodium falciparum anti-malarial drug resistance markers in pfk13-propeller, pfcrt and pfmdr1 genes in isolates from treatment failure patients in Democratic Republic of Congo, 2018–2019
por: Yobi, Doudou M., et al.
Publicado: (2021)

Ring-stage growth arrest: Metabolic basis of artemisinin tolerance in Plasmodium falciparum
por: Yu, Xinyu, et al.
Publicado: (2022)

Application of loop-mediated isothermal amplification combined with lateral flow assay visualization of Plasmodium falciparum kelch 13 C580Y mutation for artemisinin resistance detection in clinical samples
por: Sanmoung, Wannida, et al.
Publicado: (2023)

Purification and initial characterization of Plasmodium falciparum K(+) channels, PfKch1 and PfKch2 produced in Saccharomyces cerevisiae
por: Molbaek, Karen, et al.
Publicado: (2020)

Localization of the ATP-binding cassette (ABC) transport proteins PfMRP1, PfMRP2, and PfMDR5 at the Plasmodium falciparum plasma membrane
por: Kavishe, Reginald A, et al.
Publicado: (2009)

Structural Modelling Prediction of Recombinant Plasmodium falciparum K13-F446I and K13-C580Y Gene by AlphaFold Method and Heterologous Expression in Spodoptera frugiperda 9 Cells
por: Yan, He, et al.
Publicado: (2022)

Identification of a Mutant PfCRT-Mediated Chloroquine Tolerance Phenotype in Plasmodium falciparum
por: Valderramos, Stephanie G., et al.
Publicado: (2010)

Regulation of Plasmodium falciparum Glideosome Associated Protein 45 (PfGAP45) Phosphorylation
por: Thomas, Divya Catherine, et al.
Publicado: (2012)

Characterisation of the Plasmodium falciparum Hsp70–Hsp90 organising protein (PfHop)
por: Gitau, Grace W., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_9b3l2vcivgh9ra28ct32aoat69