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Clonal germinal center B cells function as a niche for T-cell lymphoma

Angioimmunoblastic T-cell lymphoma (AITL) is proposed to be initiated by age-related clonal hematopoiesis (ACH) with TET2 mutations, whereas the G17V RHOA mutation in immature cells with TET2 mutations promotes the development of T follicular helper (T(FH))-like tumor cells. Here, we investigated th...

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Detalles Bibliográficos
Autores principales: Fujisawa, Manabu, Nguyen, Tran B., Abe, Yoshiaki, Suehara, Yasuhito, Fukumoto, Kota, Suma, Sakurako, Makishima, Kenichi, Kaneko, Chihiro, Nguyen, Yen T.M., Usuki, Kensuke, Narita, Kentaro, Matsue, Kosei, Nakamura, Naoya, Ishikawa, Shumpei, Miura, Fumihito, Ito, Takashi, Suzuki, Ayako, Suzuki, Yutaka, Mizuno, Seiya, Takahashi, Satoru, Chiba, Shigeru, Sakata-Yanagimoto, Mamiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653021/
https://www.ncbi.nlm.nih.gov/pubmed/35921527
http://dx.doi.org/10.1182/blood.2022015451