Aberrant MYCN expression drives oncogenic hijacking of EZH2 as a transcriptional activator in peripheral T-cell lymphoma

Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of hematological cancers arising from the malignant transformation of mature T cells. In a cohort of 28 PTCL cases, we identified recurrent overexpression of MYCN, a member of the MYC family of oncogenic transcription factors. Approximately...

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Detalles Bibliográficos
Autores principales: Vanden Bempt, Marlies, Debackere, Koen, Demeyer, Sofie, Van Thillo, Quentin, Meeuws, Nienke, Prieto, Cristina, Provost, Sarah, Mentens, Nicole, Jacobs, Kris, Gielen, Olga, Nittner, David, Ogawa, Seishi, Kataoka, Keisuke, Graux, Carlos, Tousseyn, Thomas, Cools, Jan, Dierickx, Daan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Lymphoid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653048/
https://www.ncbi.nlm.nih.gov/pubmed/35960849
http://dx.doi.org/10.1182/blood.2022016428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653048/
https://www.ncbi.nlm.nih.gov/pubmed/35960849
http://dx.doi.org/10.1182/blood.2022016428

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