Noncanonical EZH2 drives retinoic acid resistance of variant acute promyelocytic leukemias

Cancer cell heterogeneity is a major driver of therapy resistance. To characterize resistant cells and their vulnerabilities, we studied the PLZF-RARA variant of acute promyelocytic leukemia, resistant to retinoic acid (RA), using single-cell multiomics. We uncovered transcriptional and chromatin he...

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Detalles Bibliográficos
Autores principales: Poplineau, Mathilde, Platet, Nadine, Mazuel, Adrien, Hérault, Léonard, N’Guyen, Lia, Koide, Shuhei, Nakajima-Takagi, Yaeko, Kuribayashi, Wakako, Carbuccia, Nadine, Haboub, Loreen, Vernerey, Julien, Oshima, Motohiko, Birnbaum, Daniel, Iwama, Atsushi, Duprez, Estelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Myeloid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653050/
https://www.ncbi.nlm.nih.gov/pubmed/35984905
http://dx.doi.org/10.1182/blood.2022015668

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653050/
https://www.ncbi.nlm.nih.gov/pubmed/35984905
http://dx.doi.org/10.1182/blood.2022015668

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