Assembly of von Willebrand factor tubules with in vivo helical parameters requires A1 domain insertion

The von Willebrand factor (VWF) glycoprotein is stored in tubular form in Weibel-Palade bodies (WPBs) before secretion from endothelial cells into the bloodstream. The organization of VWF in the tubules promotes formation of covalently linked VWF polymers and enables orderly secretion without polyme...

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Detalles Bibliográficos
Autores principales: Javitt, Gabriel, Yeshaya, Noa, Khmelnitsky, Lev, Fass, Deborah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653096/
https://www.ncbi.nlm.nih.gov/pubmed/36179246
http://dx.doi.org/10.1182/blood.2022017153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653096/
https://www.ncbi.nlm.nih.gov/pubmed/36179246
http://dx.doi.org/10.1182/blood.2022017153

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