Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix-metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation

During immune-complex-mediated arthritis (ICA), severe cartilage destruction is mediated by Fcγ receptors (FcγRs) (mainly FcγRI), cytokines (e.g. IL-1), and enzymes (matrix metalloproteinases (MMPs)). IL-13, a T helper 2 (Th2) cytokine abundantly found in synovial fluid of patients with rheumatoid a...

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Detalles Bibliográficos
Autores principales: Nabbe, Karin CAM, van Lent, Peter LEM, Holthuysen, Astrid EM, Sloëtjes, Annet W, Koch, Alisa E, Radstake, Timothy RDJ, van den Berg, Wim B
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1065337/
https://www.ncbi.nlm.nih.gov/pubmed/15743487
http://dx.doi.org/10.1186/ar1502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1065337/
https://www.ncbi.nlm.nih.gov/pubmed/15743487
http://dx.doi.org/10.1186/ar1502

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