p53-armed oncolytic adenovirus induces autophagy and apoptosis in KRAS and BRAF-mutant colorectal cancer cells

Colorectal cancer (CRC) cells harboring KRAS or BRAF mutations show a more-malignant phenotype than cells with wild-type KRAS and BRAF. KRAS/BRAF–wild-type CRCs are sensitive to epidermal growth factor receptor (EGFR)-targeting agents, whereas KRAS/BRAF–mutant CRCs are resistant due to constitutive...

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Detalles Bibliográficos
Autores principales: Tamura, Shuta, Tazawa, Hiroshi, Hori, Naoto, Li, Yuncheng, Yamada, Motohiko, Kikuchi, Satoru, Kuroda, Shinji, Urata, Yasuo, Kagawa, Shunsuke, Fujiwara, Toshiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653454/
https://www.ncbi.nlm.nih.gov/pubmed/37972012
http://dx.doi.org/10.1371/journal.pone.0294491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653454/
https://www.ncbi.nlm.nih.gov/pubmed/37972012
http://dx.doi.org/10.1371/journal.pone.0294491

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