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Conserved metabolic regulator ArcA responds to oxygen availability, iron limitation, and cell envelope perturbations during bacteremia

Gram-negative facultative anaerobes often cause bacteremia, a systemic infection associated with severe clinical outcomes. ArcAB, a two-component regulatory system that represses aerobic respiration, is a key mediator of metabolic adaptation for such bacteria. Using targeted mutational analysis info...

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Detalles Bibliográficos
Autores principales: Brown, Aric N., Anderson, Mark T., Smith, Sara N., Bachman, Michael A., Mobley, Harry L. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653796/
https://www.ncbi.nlm.nih.gov/pubmed/37681955
http://dx.doi.org/10.1128/mbio.01448-23