Exploiting a rodent cell block for intrinsic resistance to HIV-1 gene expression in human T cells

HIV-1 virion production is inefficient in cells derived from mice and other rodents reflecting cell-intrinsic defects to interactions between the HIV-1 auxiliary proteins Tat and Rev and host dependency factors CCNT1 (Cyclin T1) and XPO1 (exportin-1, also known as CRM1), respectively. In human cells...

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Detalles Bibliográficos
Autores principales: Behrens, Ryan T., Rajashekar, Jyothi Krishnaswamy, Bruce, James W., Evans, Edward L., Hansen, Amelia M., Salazar-Quiroz, Natalia, Simons, Lacy M., Ahlquist, Paul, Hultquist, Judd F., Kumar, Priti, Sherer, Nathan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653828/
https://www.ncbi.nlm.nih.gov/pubmed/37676006
http://dx.doi.org/10.1128/mbio.00420-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653828/
https://www.ncbi.nlm.nih.gov/pubmed/37676006
http://dx.doi.org/10.1128/mbio.00420-23

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