Phosphoprotein phosphatase activity positively regulates oligomeric pyrin to trigger inflammasome assembly in phagocytes

Pyrin is a pattern-recognition receptor in phagocytes that triggers caspase-1 inflammasome assembly in response to bacterial toxins and effectors that inactivate RhoA. Pyrin contains oligomerization domains and is negatively regulated by phosphorylation of two residues, S205 and S241 (murine) or S20...

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Detalles Bibliográficos
Autores principales: Malik, Haleema S., Magnotti, Flora, Loeven, Nicole A., Delgado, Jose M., Kettenbach, Arminja N., Henry, Thomas, Bliska, James B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653879/
https://www.ncbi.nlm.nih.gov/pubmed/37787552
http://dx.doi.org/10.1128/mbio.02066-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653879/
https://www.ncbi.nlm.nih.gov/pubmed/37787552
http://dx.doi.org/10.1128/mbio.02066-23

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