Dengue virus NS1 secretion is regulated via importin-subunit β1 controlling expression of the chaperone GRp78 and targeted by the clinical drug ivermectin

Dengue virus (DENV) is a major human pathogen. An important pathogenicity factor is non-structural protein 1 (NS1) required for viral replication and secreted from infected cells. A clinical study indicated that the anti-parasitic drug ivermectin lowers NS1 blood levels without affecting viremia. Iv...

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Detalles Bibliográficos
Autores principales: Denolly, Solène, Guo, Hongbo, Martens, Miriam, Płaszczyca, Anna, Scaturro, Pietro, Prasad, Vibhu, Kongmanas, Kessiri, Punyadee, Nuntaya, Songjaeng, Adisak, Mairiang, Dumrong, Pichlmair, Andreas, Avirutnan, Panisadee, Bartenschlager, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653883/
https://www.ncbi.nlm.nih.gov/pubmed/37702492
http://dx.doi.org/10.1128/mbio.01441-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653883/
https://www.ncbi.nlm.nih.gov/pubmed/37702492
http://dx.doi.org/10.1128/mbio.01441-23

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