Cargando…

Dengue virus NS1 secretion is regulated via importin-subunit β1 controlling expression of the chaperone GRp78 and targeted by the clinical drug ivermectin

Dengue virus (DENV) is a major human pathogen. An important pathogenicity factor is non-structural protein 1 (NS1) required for viral replication and secreted from infected cells. A clinical study indicated that the anti-parasitic drug ivermectin lowers NS1 blood levels without affecting viremia. Iv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Denolly, Solène, Guo, Hongbo, Martens, Miriam, Płaszczyca, Anna, Scaturro, Pietro, Prasad, Vibhu, Kongmanas, Kessiri, Punyadee, Nuntaya, Songjaeng, Adisak, Mairiang, Dumrong, Pichlmair, Andreas, Avirutnan, Panisadee, Bartenschlager, Ralf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653883/ https://www.ncbi.nlm.nih.gov/pubmed/37702492 http://dx.doi.org/10.1128/mbio.01441-23

Ejemplares similares

Development of a Singleplex Real-Time Reverse Transcriptase PCR Assay for Pan-Dengue Virus Detection and Quantification
por: Songjaeng, Adisak, et al.
Publicado: (2022)

Immortalized stem cell-derived hepatocyte-like cells: An alternative model for studying dengue pathogenesis and therapy
por: Kongmanas, Kessiri, et al.
Publicado: (2020)

RNA Sequencing Data Sets and Their Whole-Genome Sequence Assembly of Dengue Virus from Three Serial Passages in Vero Cells
por: Wongsurawat, Thidathip, et al.
Publicado: (2021)

Analytical and diagnostic performance characteristics of reverse-transcriptase loop-mediated isothermal amplification assays for dengue virus serotypes 1–4: A scoping review to inform potential use in portable molecular diagnostic devices
por: Arkell, Paul, et al.
Publicado: (2023)

Dengue and the Lectin Pathway of the Complement System
por: Kraivong, Romchat, et al.
Publicado: (2021)

High performance dengue virus antigen-based serotyping-NS1-ELISA (plus): A simple alternative approach to identify dengue virus serotypes in acute dengue specimens
por: Prommool, Tanapan, et al.
Publicado: (2021)

Synergistic anti-SARS-CoV-2 activity of repurposed anti-parasitic drug combinations
por: Jitobaom, Kunlakanya, et al.
Publicado: (2022)

Secreted NS1 of Dengue Virus Attaches to the Surface of Cells via Interactions with Heparan Sulfate and Chondroitin Sulfate E
por: Avirutnan, Panisadee, et al.
Publicado: (2007)

Application of One-Step Reverse Transcription Droplet Digital PCR for Dengue Virus Detection and Quantification in Clinical Specimens
por: Mairiang, Dumrong, et al.
Publicado: (2021)

Ultrastructural Features of Human Liver Specimens from Patients Who Died of Dengue Hemorrhagic Fever
por: Win, Min Min, et al.
Publicado: (2019)

Differential critical residues on the overlapped region of the non-structural protein-1 recognized by flavivirus and dengue virus cross-reactive monoclonal antibodies
por: Luangaram, Prasit, et al.
Publicado: (2022)

A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle
por: Płaszczyca, Anna, et al.
Publicado: (2019)

GRP78 in lung cancer
por: Xia, Shengkai, et al.
Publicado: (2021)

Smartphone multiplex microcapillary diagnostics using Cygnus: Development and evaluation of rapid serotype-specific NS1 detection with dengue patient samples
por: Needs, Sarah Helen, et al.
Publicado: (2022)

Mitochondrial metabolic regulation by GRP78
por: Prasad, Manoj, et al.
Publicado: (2017)

Differential requirement of GRP94 and GRP78 in mammary gland development
por: Zhu, Genyuan, et al.
Publicado: (2014)

Potential Phosphorylation of Viral Nonstructural Protein 1 in Dengue Virus Infection
por: Dechtawewat, Thanyaporn, et al.
Publicado: (2021)

Ultrasensitive Detection of GRP78 in Exosomes and Observation of Migration and Proliferation of Cancer Cells by Application of GRP78-Containing Exosomes
por: Tsurusawa, Naoko, et al.
Publicado: (2022)

GRP78-CAR T cell effector function against solid and brain tumors is controlled by GRP78 expression on T cells
por: Ibanez, Jorge, et al.
Publicado: (2023)

Conservation of Importin α Function in Apicomplexans: Ivermectin and GW5074 Target Plasmodium falciparum Importin α and Inhibit Parasite Growth in Culture
por: Walunj, Sujata B., et al.
Publicado: (2022)

Grp78 promotes the invasion of hepatocellular carcinoma
por: Su, Rongjian, et al.
Publicado: (2010)

GRP78 at the Centre of the Stage in Cancer and Neuroprotection
por: Casas, Caty
Publicado: (2017)

Targeting the GRP78 Pathway for Cancer Therapy
por: Lu, Guanhua, et al.
Publicado: (2020)

GRP78: A cell's response to stress
por: Ibrahim, Ibrahim M., et al.
Publicado: (2019)

Expression and release of glucose-regulated protein-78 (GRP78) in multiple myeloma
por: Steiner, Normann, et al.
Publicado: (2017)

The Endogenous GRP78 Interactome in Human Head and Neck Cancers: A Deterministic Role of Cell Surface GRP78 in Cancer Stemness
por: Chen, Hsin-Ying, et al.
Publicado: (2018)

Unmasking the role of mast cells in dengue
por: Avirutnan, Panisadee, et al.
Publicado: (2013)

Involvement of Membrane GRP78 in Trophoblastic Cell Fusion
por: Fradet, Sarah, et al.
Publicado: (2012)

The Interplay between Glucose-Regulated Protein 78 (GRP78) and Steroids in the Reproductive System
por: Hebert-Schuster, Marylise, et al.
Publicado: (2018)

Cross-reactive antibodies targeting surface-exposed non-structural protein 1 (NS1) of dengue virus-infected cells recognize epitopes on the spaghetti loop of the β-ladder domain
por: Kraivong, Romchat, et al.
Publicado: (2022)

The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection
por: Carlos, Anthony J., et al.
Publicado: (2021)

Upregulation of Phosphorylated HSP27, PRDX2, GRP75, GRP78 and GRP94 in Acquired Middle Ear Cholesteatoma Growth
por: Ho, Kuen Yao, et al.
Publicado: (2013)

Co-downregulation of GRP78 and GRP94 Induces Apoptosis and Inhibits Migration in Prostate Cancer Cells
por: Lu, Tong, et al.
Publicado: (2019)

GRP78 inhibits macrophage adhesion via SR-A
por: Bai, Hui, et al.
Publicado: (2014)

Probing the ATP Site of GRP78 with Nucleotide Triphosphate Analogs
por: Hughes, Scott J., et al.
Publicado: (2016)

The meta and bioinformatics analysis of GRP78 expression in gastric cancer
por: Zheng, Hua-Chuan, et al.
Publicado: (2017)

GRP78 Is a Targetable Receptor on Cancer and Stromal Cells
por: Araujo, Nathalia, et al.
Publicado: (2018)

GRP78 targeting: Hitting two birds with a stone
por: Elfiky, Abdo A., et al.
Publicado: (2020)

GRP 78 antibodies are associated with clinical phenotype in neuromyelitis optica
por: Shimizu, Fumitaka, et al.
Publicado: (2019)

ILDR2 stabilization is regulated by its interaction with GRP78
por: Watanabe, Kazuhisa, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_6jciki3oec1ffs9gt69jisbj95