Antibiotic that inhibits trans-translation blocks binding of EF-Tu to tmRNA but not to tRNA

trans-Translation is conserved throughout bacteria and is essential in many species. High-throughput screening identified a tetrazole-based trans-translation inhibitor, KKL-55, that has broad-spectrum antibiotic activity. A biotinylated version of KKL-55 pulled down elongation factor thermo-unstable...

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Detalles Bibliográficos
Autores principales: Marathe, Neeraja, Nguyen, Ha An, Alumasa, John N., Kuzmishin Nagy, Alexandra B., Vazquez, Michael, Dunham, Christine M., Keiler, Kenneth C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653918/
https://www.ncbi.nlm.nih.gov/pubmed/37681945
http://dx.doi.org/10.1128/mbio.01461-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653918/
https://www.ncbi.nlm.nih.gov/pubmed/37681945
http://dx.doi.org/10.1128/mbio.01461-23

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