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Interferon-stimulated gene TDRD7 interacts with AMPK and inhibits its activation to suppress viral replication and pathogenesis

Many viruses activate cellular autophagy in infected cells to facilitate their replication. Recently, we identified an interferon (IFN)-stimulated gene (ISG) Tudor domain containing 7 (TDRD7), which inhibits viral replication by blocking autophagy pathway. Here, we present a molecular mechanism for...

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Detalles Bibliográficos
Autores principales: Chakravarty, Sukanya, Subramanian, Gayatri, Popli, Sonam, Veleeparambil, Manoj, Fan, Shumin, Chakravarti, Ritu, Chattopadhyay, Saurabh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653931/
https://www.ncbi.nlm.nih.gov/pubmed/37712680
http://dx.doi.org/10.1128/mbio.00611-23