Systemic application of bone-targeting peptidoglycan hydrolases as a novel treatment approach for staphylococcal bone infection

The current standard of treatment for chronic staphylococcal osteomyelitis entails high doses of antibiotics over the course of several weeks. Biofilm-associated and intracellular persisters are key factors contributing to therapeutic failure. Additionally, systemic application results in low concen...

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Detalles Bibliográficos
Autores principales: Keller, Anja P., Huemer, Markus, Chang, Chun-Chi, Mairpady Shambat, Srikanth, Bjurnemark, Caroline, Oberortner, Nicole, Santschi, Michaela V., Zinsli, Léa V., Röhrig, Christian, Sobieraj, Anna M., Shen, Yang, Eichenseher, Fritz, Zinkernagel, Annelies S., Loessner, Martin J., Schmelcher, Mathias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653945/
https://www.ncbi.nlm.nih.gov/pubmed/37768041
http://dx.doi.org/10.1128/mbio.01830-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653945/
https://www.ncbi.nlm.nih.gov/pubmed/37768041
http://dx.doi.org/10.1128/mbio.01830-23

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