IdeS, a secreted proteinase of Streptococcus pyogenes, is bound to a nuclease at the bacterial surface where it inactivates opsonizing IgG antibodies

The important bacterial pathogen Streptococcus pyogenes secretes IdeS (immunoglobulin G-degrading enzyme of S. pyogenes), a proteinase that cleaves human immunoglobulin G (IgG) antibodies in the hinge region resulting in Fc (fragment crystallizable) and F(ab')(2) (fragment antigen-binding) frag...

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Detalles Bibliográficos
Autores principales: Frick, Inga-Maria, Happonen, Lotta, Wrighton, Sebastian, Nordenfelt, Pontus, Björck, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654033/
https://www.ncbi.nlm.nih.gov/pubmed/37838172
http://dx.doi.org/10.1016/j.jbc.2023.105345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654033/
https://www.ncbi.nlm.nih.gov/pubmed/37838172
http://dx.doi.org/10.1016/j.jbc.2023.105345

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